Printing with a 0.25 nozzle is much more fickle than with a 0.4mm.
If you have blockages, here are the points to apply in this order:
1) Raise the extrusion temperature a little (5 to 15°C). Because the smaller the nozzle, the harder the filament becomes to push. Increasing the temperature allows the material to flow a little more and reduces the pressure.
2) Tighten the compressor screws a little more to increase the drive pressure
3) Lower the print speed. The smaller the nozzle, the less it will withstand high speeds.
4) No filament loaded with nozzles below 0.4mm. Because the loads will clog the small nozzles for sure.